I had problems with all the main anti-virus programs.
Norton, McAfee and Kaspersky all tried to prevent me from running perfectly ok programs (like Sybase and JBuilder for instance), and the crowning glory ended up with Kaspersky refusing to allow me to open up an html file that I'd written myself!
At that point I gave up, because I'd never had a genuine virus anyway. I had Ubuntu on the desktop and am careful what gets opened or visited on the laptop. I've not had any trouble at all, I've done a couple of online scans on the Symantec website to confirm to myself that I haven't got anything, so everything is just peachy with no anti-virus whatever.